Telomeres in cancer and aging: lessons from the mouse

被引：25

作者：

Blasco, MA ^{[1
]}

机构：

[1] Natl Ctr Biotechnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

CANCER LETTERS | 2003年 / 194卷 / 02期

关键词：

telomere; telomerase; TERC; TERT; DNA repair; cancer; aging; knockout; mouse model; telomere capping; tumorigenesis; transformation; tumor;

D O I：

10.1016/S0304-3835(02)00705-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：183 / 188

页数：6

共 47 条

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