The role of eosinophils in the pathogenesis of asthma

被引：173

作者：

Kay, AB

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Leukocyte Biol Sect, London SW7 2AZ, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2005年 / 11卷 / 04期

关键词：

D O I：

10.1016/j.molmed.2005.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two recent papers have addressed the ever-intriguing question of the role of eosinophils; in asthma. Both groups used experimental models of airway inflammation in mice that were gene targeted to selectively ablate the eosinophil lineage. One group found that eosinophils were required for both airway hyperresponsiveness; and mucus accumulation. The other demonstrated a 'critical role'for the cell in airway remodelling. The results, although largely confirmatory of previous studies both in mice and humans, put the eosinophil firmly back on the asthma stage and strengthen the case for developing effective eosinophil-depleting agents for clinical use.

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收藏

页码：148 / 152

页数：5

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