Germ cell sex determination: a collaboration between soma and germline

被引：48

作者：

Murray, Sheryl M. ^{[1
]}

Yang, Shu Yuan ^{[1
]}

Van Doren, Mark ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 06期

关键词：

RNA-BINDING PROTEIN; SPERM-OOCYTE SWITCH; CAENORHABDITIS-ELEGANS; DROSOPHILA-MELANOGASTER; OVARIAN-TUMOR; C-ELEGANS; X-CHROMOSOME; INDUCTIVE SIGNALS; DETERMINING GENE; MUSCA-DOMESTICA;

D O I：

10.1016/j.ceb.2010.09.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sex determination is regulated very differently in the soma vs. the germline, yet both processes are critical for the creation of the male and female gametes. In general, the soma plays an essential role in regulating sexual identity of the germline. However, in some species, such as Drosophila and mouse, the sex chromosome constitution of the germ cells makes an autonomous contribution to germline sexual development. Here we review how the soma and germline cooperate to determine germline sexual identity for some important model systems, the fly, the worm and the mouse, and discuss some of the implications of 'dual control' (soma plus germline) as compared to species where germline sex is dictated only by the surrounding soma.

引用

页码：722 / 729

页数：8

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