Minor diterpenoids from cascarilla (Croton eluteria Bennet) and evaluation of the cascarilla extract and cascarillin effects on gastric acid secretion

被引：12

作者：

Appendino, G

Borrelli, F

Capasso, R

Campagnuolo, C

Fattorusso, E

Petrucci, F

Taglialatela-Scafati, O

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Piemonte Orientale, DISCAFF, I-28100 Novara, Italy

[3] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2003年 / 51卷 / 24期

关键词：

cascarilla; Croton eluteria; diterpenes; halimane; clerodanes; gastric secretion; digestive liqueurs;

D O I：

10.1021/jf034780h

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Three new diterpenoids belonging to the clerodane (2-3) and halimane (4) structural types have been isolated from the bark of Croton eluteria Bennet, commonly known as cascarilla. Their structures have been fully characterized by spectroscopic means. Cascarilla extract and its major component, cascarillin, were found to significantly increase histamine-induced gastric acid secretion in the mouse stomach. These preliminary results provide the first rationale for the use of cascarilla in bitter preparations aimed at improving digestion.

引用

页码：6970 / 6974

页数：5