A short enantioselective synthesis of 1-deoxy-L-xylulose by antibody catalysis

被引：34

作者：

Shabat, D

List, B

Lerner, RA

Barbas, CF

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(98)02699-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new efficient synthesis of 1-deoxy-L-xylulose (I) is presented The key step is achieved by a highly enantioselective aldol addition of hydroxyacetone to benzyloxyacetaldehyde via antibody catalysis. The synthesis described here should provide a convenient route to isotopically labeled derivatives. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1437 / 1440

页数：4

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