Correlation with redox potentials and inhibitory effects on Epstein-Barr virus activation of azaanthraquinones

被引：18

作者：

Koyama, J ^{[1
]}

Morita, I

Tagahara, K

Osakai, T

Hotta, H

Yang, MX

Mukainaka, T

Nishino, H

Tokuda, H

机构：

[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan

[2] Kobe Univ, Fac Sci, Dept Chem, Kobe, Hyogo 6578501, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 6028566, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 09期

关键词：

azaanthraquinone; Epstein-Barr virus activation; redox potential; cyclic voltammetry; anti-tumor promoting effect;

D O I：

10.1248/cpb.49.1214

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e., the atomic charge at O-11 as an additional parameter.

引用

页码：1214 / 1216

页数：3

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