Notch signaling is an important regulator of type 2 immunity

被引：235

作者：

Tu, LL

Fang, TC

Artis, D

Shestova, O

Pross, SE

Maillard, I

Pear, WS ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

[5] Univ Penn, Div Hematol Oncol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 08期

关键词：

D O I：

10.1084/jem.20050923

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4(+) T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.

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收藏

页码：1037 / 1042

页数：6

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