Regulation of cell adhesion by PAI-1

被引：138

作者：

Loskutoff, DJ ^{[1
]}

Curriden, SA ^{[1
]}

Hu, G ^{[1
]}

Deng, G ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA

来源：

APMIS | 1999年 / 107卷 / 01期

关键词：

Type I plasminogen activator inhibitor (PAI-1); vitronectin (VN); urokinase plasminogen activator receptor (uPAR); integrins; cell adhesion;

D O I：

10.1111/j.1699-0463.1999.tb01526.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I plasminogen activator inhibitor (PAI-I) is the primary inhibitor of tissue- and urokinase-type plasminogen activators. It circulates in plasma complexed with vitronectin (VN), the primary PAI-1 binding protein. The somatomedin B (SMB) domain of VN contains both the high affinity PAI-I binding site and the specific site for urokinase plasminogen activator receptor (uPAR). PAI-1 is able to regulate uPAR-mediated cell adhesion by competing with uPAR for VN binding. Binding of PAI-1 to SMD may also affect integrin-mediated cell adhesion to VN by hindering integrin binding to the RGD sequence adjacent to the uPAR binding site.

引用

页码：54 / 61

页数：8

共 57 条

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