Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid broblasts in H2O2-induced premature senescence and interplay with p38αMAPK

被引：28

作者：

Chretien, Aline ^{[1
]}

Piront, Neil ^{[1
]}

Delaive, Edouard ^{[1
]}

Demazy, Catherine ^{[1
]}

Ninane, Noelle ^{[1
]}

Toussaint, Olivier ^{[1
]}

机构：

[1] Fac Univ Notre Dame Paix, Univ Namur, Unit Res Cellular Biol, B-5000 Namur, Belgium

来源：

FEBS LETTERS | 2008年 / 582卷 / 12期

关键词：

H(2)O(2); siRNA; cellular senescence; caveolin; 1; fibroblasts; stress-induced premature senescence;

D O I：

10.1016/j.febslet.2008.04.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of IMR-90 human diploid. broblasts with a sublethal concentration of H(2)O(2) induces premature senescence. We investigated the protein abundance, subcellular localization and involvement of caveolin 1 in premature senescence. Caveolin 1 is a scaffolding protein able to concentrate and organize signaling molecules within the caveolae membrane domains. We report the first evidence of increased nuclear and cytoplasmic localization of caveolin 1 during establishment of H(2)O(2)-induced premature senescence. Moreover, we demonstrate that phosphorylation of caveolin 1 during treatment with H(2)O(2) is dependent on p38 alpha mitogen-activated protein kinase. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1685 / 1692

页数：8

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