Human dendritic cells: Potent antigen-presenting cells at the crossroads of innate and adaptive immunity

被引:237
作者
Rossi, M
Young, JW
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Lab Cellular Immunobiol, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Allogen Bone Marrows Transplantat Serv, New York, NY 10021 USA
[4] Mem Sloan Kettering Canc Ctr, Clin Immunol Serv, New York, NY 10021 USA
[5] Mem Sloan Kettering Canc Ctr, Div Hematol Oncol, New York, NY 10021 USA
[6] Cornell Univ, Weill Med Coll, New York, NY 10021 USA
关键词
D O I
10.4049/jimmunol.175.3.1373
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DCs) are specialized, bone marrow-derived Leukocytes that are critical to the development of immunity. Investigators have emphasized the role of DCs in initiating adaptive or acquired MHC-restricted, Ag-specific T cell responses. More recent evidence supports important roles for DCs in the onset of innate immunity and peripheral tolerance. Progress in the generation of DCs from defined hemopoietic precursors in vitro has revealed the heterogeneity of these APCs and their attendant divisions of labor. This review will address these developments in an attempt to integrate the activities of different DCs in coordinating innate and adaptive immunity.
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收藏
页码:1373 / 1381
页数:9
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