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G1 to S phase cell cycle transition in somatic and embryonic stem cells

被引：130
作者：
Neganova, Irina [1 ,2 ]
Lako, Majlinda [1 ,2 ]
机构：
[1] Newcastle Univ, Inst Human Genet, Int Ctr Life, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England
[2] Newcastle Univ, North East Inst Stem Cell Res, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England
来源：
JOURNAL OF ANATOMY | 2008年 / 213卷 / 01期
基金：
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
cyclin D1; 2; 3; cyclin E; embryonic stem cells; G1 to S transition; pluripotency; pRb;
D O I：
10.1111/j.1469-7580.2008.00931.x
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
It is well known that G1 to S phase transition is tightly regulated by the expression and phosphorylation of a number of well-characterized cyclins, cyclin-dependent kinases and members of the retinoblastoma gene family. In this review we discuss the role of these components in regulation of G1 to S phase transition in somatic cells and human embryonic stem cells. Most importantly, we discuss some new tenable links between maintenance of pluripotency and cell cycle regulation in embryonic stem cells by describing the role that master transcription factors play in this process. Finally, the differences in cell cycle regulation between murine and human embryonic stem cells are highlighted, raising interesting questions regarding their biology and stages of embryonic development from which they have been derived.
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页码：30 / 44
页数：15
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