Preparation and characterization of pH sensitive poly(N-vinyl-2-pyrrolidone/itaconic acid) copolymer hydrogels

被引:70
作者
Chen, KS
Ku, YA
Lin, HR
Yan, TR
Sheu, DC
Chen, TM
Lin, FH
机构
[1] Tatung Univ, Dept Mat Engn, Taipei 10451, Taiwan
[2] So Taiwan Univ Technol, Dept Chem Engn, Tainan, Taiwan
[3] Tatung Univ, Dept Bioengn, Taipei 10451, Taiwan
[4] Tri Serv Gen Hosp, Burn Ctr, Dept Surg, Taipei, Taiwan
[5] Natl Taiwan Univ, Coll Engn & Med, Inst Biomed Engn, Taipei 10764, Taiwan
关键词
pH sensitive; N-vinyl-2-pyrrolidone; itaconic acid; hydrogel;
D O I
10.1016/j.matchemphys.2004.12.037
中图分类号
T [工业技术];
学科分类号
08 [工学];
摘要
Poly(N-vinyl-2-pyrrolidone) (PVP) is widely used in medicine due to its high biocompatibility. In this study, itaconic acid (IA) was co-polymerized with N-vinyl-2-pyrrolidone (NVP) monomer to prepare the pH sensitive hydrogels. These copolymer hydrogels were prepared using ultra-violet (UV) induced methods at ambient temperature. Monomer and cross-linking agent (NAP-methylene-bisacrylamide (MBAAm)) concentration effects on preparation of this copolymer hydrogel were investigated using swelling, FIF-IR, and SEM. The prepared copolymer hydrogel is highly pH sensitive. The percentage swell of the copolymer hydrogels was found to increase from 150 to 3011% as the pH value of the swelling solution varied from 4 to 10. These pH sensitive copolymer hydrogels present a promising approach for drug delivery applications. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:484 / 489
页数:6
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