Preparation and characterization of pH sensitive poly(N-vinyl-2-pyrrolidone/itaconic acid) copolymer hydrogels

被引：70

作者：

Chen, KS

Ku, YA

Lin, HR

Yan, TR

Sheu, DC

Chen, TM

Lin, FH

机构：

[1] Tatung Univ, Dept Mat Engn, Taipei 10451, Taiwan

[2] So Taiwan Univ Technol, Dept Chem Engn, Tainan, Taiwan

[3] Tatung Univ, Dept Bioengn, Taipei 10451, Taiwan

[4] Tri Serv Gen Hosp, Burn Ctr, Dept Surg, Taipei, Taiwan

[5] Natl Taiwan Univ, Coll Engn & Med, Inst Biomed Engn, Taipei 10764, Taiwan

来源：

MATERIALS CHEMISTRY AND PHYSICS | 2005年 / 91卷 / 2-3期

关键词：

pH sensitive; N-vinyl-2-pyrrolidone; itaconic acid; hydrogel;

D O I：

10.1016/j.matchemphys.2004.12.037

中图分类号：

T [工业技术];

学科分类号：

08 [工学];

摘要：

Poly(N-vinyl-2-pyrrolidone) (PVP) is widely used in medicine due to its high biocompatibility. In this study, itaconic acid (IA) was co-polymerized with N-vinyl-2-pyrrolidone (NVP) monomer to prepare the pH sensitive hydrogels. These copolymer hydrogels were prepared using ultra-violet (UV) induced methods at ambient temperature. Monomer and cross-linking agent (NAP-methylene-bisacrylamide (MBAAm)) concentration effects on preparation of this copolymer hydrogel were investigated using swelling, FIF-IR, and SEM. The prepared copolymer hydrogel is highly pH sensitive. The percentage swell of the copolymer hydrogels was found to increase from 150 to 3011% as the pH value of the swelling solution varied from 4 to 10. These pH sensitive copolymer hydrogels present a promising approach for drug delivery applications. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：484 / 489

页数：6

共 18 条

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