Hydrogels: from controlled release to pH-responsive drug delivery

被引：1336

作者：

Gupta, P ^{[1
]}

Vermani, K ^{[1
]}

Garg, S ^{[1
]}

机构：

[1] NIPER, SAS Nagar 160062, Punjab, India

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 10期

关键词：

D O I：

10.1016/S1359-6446(02)02255-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release.

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页码：569 / 579

页数：11

相关论文

共 70 条

[1] Gelatin poly(ethylene oxide) semi-interpenetrating polymer network with pH-sensitive swelling and enzyme-degradable properties for oral drug delivery [J].

Amiji, M ;

Tailor, R ;

Ly, MK ;

Goreham, J .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1997, 23 (06) :575-582

[2] MULTIPLE PHASES OF POLYMER GELS [J].

ANNAKA, M ;

TANAKA, T .

NATURE, 1992, 355 (6359) :430-432

[3]

[Anonymous], ENCY CHEM TECHNOLOGY

[4] SOLUBILITY EFFECTS ON DRUG TRANSPORT THROUGH PH-SENSITIVE, SWELLING-CONTROLLED RELEASE SYSTEMS - TRANSPORT OF THEOPHYLLINE AND METOCLOPRAMIDE MONOHYDROCHLORIDE [J].

BETTINI, R ;

COLOMBO, P ;

PEPPAS, NA .

JOURNAL OF CONTROLLED RELEASE, 1995, 37 (1-2) :105-111

[5] In vitro evaluation of a pH-sensitive hydrogel for control of GI drug delivery from silicone-based matrices [J].

Bilia, A ;

Carelli, V ;

DiColo, G ;

Nannipieri, E .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 130 (01) :83-92

[6] Pulsatile local delivery of thrombolytic and antithrombotic agents using poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels [J].

Brazel, CS ;

Peppas, NA .

JOURNAL OF CONTROLLED RELEASE, 1996, 39 (01) :57-64

[7] Characterization of glucose-mediated insulin release from implantable polymers [J].

Brown, LR ;

Edelman, ER ;

FischelGhodsian, F ;

Langer, R .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (12) :1341-1345

[8] Chronopharmacokinetics - Current status [J].

Bruguerolle, B .

CLINICAL PHARMACOKINETICS, 1998, 35 (02) :83-94

[9] GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH [J].

CHEN, GH ;

HOFFMAN, AS .

NATURE, 1995, 373 (6509) :49-52

[10] Gastric retention properties of superporous hydrogel composites [J].

Chen, J ;

Blevins, WE ;

Park, H ;

Park, K .

JOURNAL OF CONTROLLED RELEASE, 2000, 64 (1-3) :39-51

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