Genetic contributions to generalized arousal of brain and behavior

被引：67

作者：

Garey, J

Goodwillie, A

Frohlich, J

Morgan, M

Gustafsson, JA

Smithies, O

Korach, KS

Ogawa, S

Pfaff, DW

机构：

[1] Rockefeller Univ, Neurobiol & Behav Lab, New York, NY 10021 USA

[2] Karolinska Inst, S-14186 Huddinge, Sweden

[3] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA

[4] NIEHS, Res Triangle Pk, NC 27709 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 19期

关键词：

estrogen; motivation; mice; genomics; estrogen receptor;

D O I：

10.1073/pnas.1633773100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-alpha), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-beta, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.

引用

页码：11019 / 11022

页数：4

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