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Genetic contributions to generalized arousal of brain and behavior

被引：67
作者：
Garey, J
Goodwillie, A
Frohlich, J
Morgan, M
Gustafsson, JA
Smithies, O
Korach, KS
Ogawa, S
Pfaff, DW
机构：
[1] Rockefeller Univ, Neurobiol & Behav Lab, New York, NY 10021 USA
[2] Karolinska Inst, S-14186 Huddinge, Sweden
[3] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA
[4] NIEHS, Res Triangle Pk, NC 27709 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 19期
关键词：
estrogen; motivation; mice; genomics; estrogen receptor;
D O I：
10.1073/pnas.1633773100
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-alpha), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-beta, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.
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页码：11019 / 11022
页数：4
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