Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice

被引:236
作者
Krezel, W
Dupont, S
Krust, A
Chambon, P
Chapman, PF
机构
[1] Cardiff Univ, Cardiff Sch Biosci, Cardiff CF10 3US, S Glam, Wales
[2] Univ Strasbourg 1, Coll France, INSERM, CNRS,Inst Genet & Biol & Cellulaire, F-67404 Illkirch Graffenstaden, France
关键词
D O I
10.1073/pnas.221451898
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Estrogens are powerful modulators of neuronal physiology and in humans may affect a broad range of functions, including reproductive, emotional, and cognitive behaviors. We studied the contribution of estrogen receptors (ERs) in modulation of emotional processes and analyzed the effects of deleting ER alpha or ER beta in mice. Behavior consistent with increased anxiety was observed principally in ER beta mutant females and was associated with a reduced threshold for the induction of synaptic plasticity in the basolateral amygdala. Local increase of 5-hydroxytryptamine 1a receptor expression in medial amygdala may contribute to these changes. Our data show that, particularly in females, there is an important role for ER beta -mediated estrogen signaling in the processing of emotional behavior.
引用
收藏
页码:12278 / 12282
页数:5
相关论文
共 46 条
[1]  
Alves SE, 2000, J COMP NEUROL, V427, P185, DOI 10.1002/1096-9861(20001113)427:2<185::AID-CNE2>3.0.CO
[2]  
2-G
[3]   Excitatory versus inhibitory GABA as a divergence point in steroid-mediated sexual differentiation of the brain [J].
Auger, AP ;
Perrot-Sinal, TS ;
McCarthy, MM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :8059-8064
[4]   Estrogen receptor null mice: What have we learned and where will they lead us? [J].
Couse, JF ;
Korach, KS .
ENDOCRINE REVIEWS, 1999, 20 (03) :358-417
[5]   Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests [J].
Crawley, JN .
BRAIN RESEARCH, 1999, 835 (01) :18-26
[6]   Regional brain function, emotion and disorders of emotion [J].
Davidson, RJ ;
Abercrombie, H ;
Nitschke, JB ;
Putnam, K .
CURRENT OPINION IN NEUROBIOLOGY, 1999, 9 (02) :228-234
[7]   THE ROLE OF THE AMYGDALA IN FEAR AND ANXIETY [J].
DAVIS, M .
ANNUAL REVIEW OF NEUROSCIENCE, 1992, 15 :353-375
[8]  
Dupont S, 2000, DEVELOPMENT, V127, P4277
[9]   Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats [J].
Edwards, HE ;
Burnham, WM ;
Mendonca, A ;
Bowlby, DA ;
MacLusky, NJ .
BRAIN RESEARCH, 1999, 838 (1-2) :136-150
[10]   Role of the basolateral nucleus of the amygdala in the formation of a phobia [J].
File, SE ;
Gonzalez, LE ;
Gallant, R .
NEUROPSYCHOPHARMACOLOGY, 1998, 19 (05) :397-405