Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin

被引：25

作者：

Gonzalez, MA

Biswas, S

Clifton, L

Corrie, PG

机构：

[1] Addenbrookes Hosp, Ctr Oncol, Cambridge CB2 2QQ, England

[2] Hutchison MRC Res Ctr, MRC, Canc Cell Unit, Cambridge CB2 2XZ, England

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 89卷 / 03期

关键词：

neuroendocrine tumour; carcinoid; streptozocin; 5-fluorouracil; LV5FU2;

D O I：

10.1038/sj.bjc.6601167

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.

引用

页码：455 / 456

页数：2

共 11 条

[1] Carcinoid tumour [J].

Caplin, ME ;

Buscombe, JR ;

Hilson, AJ ;

Jones, AL ;

Watkinson, AF ;

Burroughs, AK .

LANCET, 1998, 352 (9130) :799-805

[2]

Cheng PNM, 1999, CANCER, V86, P944, DOI 10.1002/(SICI)1097-0142(19990915)86:6<944::AID-CNCR8>3.3.CO

[3]

2-G

[4] HIGH-DOSE FOLINIC ACID AND 5-FLUOROURACIL BOLUS AND CONTINUOUS INFUSION IN ADVANCED COLORECTAL-CANCER [J].

DEGRAMONT, A ;

KRULIK, M ;

CADY, J ;

LAGADEC, B ;

MAISANI, JE ;

LOISEAU, JP ;

GRANGE, JD ;

GONZALEZCANALL, G ;

DEMUYNCK, B ;

LOUVET, C ;

SEROKA, J ;

DRAY, C ;

DEBRAY, J .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1988, 24 (09) :1499-1503

[5] Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French intergroup study [J].

deGramont, A ;

Basset, JF ;

Milan, C ;

Rougier, P ;

Bouche, O ;

Etienne, PL ;

Morvan, F ;

Louvet, C ;

Guillot, C ;

Francois, E ;

Bedenne, L .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :808-815

[6]

Fjällskog MLH, 2001, CANCER, V92, P1101, DOI 10.1002/1097-0142(20010901)92:5<1101::AID-CNCR1426>3.0.CO

[7]

2-V

[8] Treatment of advanced neuroendocrine tumours using combination chemotherapy with lomustine and 5-fluorouracil [J].

Kaltsas, GA ;

Mukherjee, JJ ;

Isidori, A ;

Kola, B ;

Plowman, PN ;

Monson, JP ;

Grossman, AB ;

Besser, GM .

CLINICAL ENDOCRINOLOGY, 2002, 57 (02) :169-183

[9] STREPTOZOCIN DOXORUBICIN, STREPTOZOCIN FLUOROURACIL, OR CHLOROZOTOCIN IN THE TREATMENT OF ADVANCED ISLET-CELL CARCINOMA [J].

MOERTEL, CG ;

LEFKOPOULO, M ;

LIPSITZ, S ;

HAHN, RG ;

KLAASSEN, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (08) :519-523

[10] STREPTOZOCIN ALONE COMPARED WITH STREPTOZOCIN PLUS FLUOROURACIL IN THE TREATMENT OF ADVANCED ISLET-CELL CARCINOMA [J].

MOERTEL, CG ;

HANLEY, JA ;

JOHNSON, LA .

NEW ENGLAND JOURNAL OF MEDICINE, 1980, 303 (21) :1189-1194

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