Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin

被引：25

作者：

Gonzalez, MA

Biswas, S

Clifton, L

Corrie, PG

机构：

[1] Addenbrookes Hosp, Ctr Oncol, Cambridge CB2 2QQ, England

[2] Hutchison MRC Res Ctr, MRC, Canc Cell Unit, Cambridge CB2 2XZ, England

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 89卷 / 03期

关键词：

neuroendocrine tumour; carcinoid; streptozocin; 5-fluorouracil; LV5FU2;

D O I：

10.1038/sj.bjc.6601167

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.

引用

页码：455 / 456

页数：2