Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol

被引：26

作者：

Hand, CE ^{[1
]}

Taylor, NJ ^{[1
]}

Honek, JF ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 05期

关键词：

ergothioneine; ovothiol; ab initio; intracellular thiols; glutathione;

D O I：

10.1016/j.bmcl.2005.01.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Intracellular naturally occurring aromatic thiols such as ergothioneine and the ovothiols have been shown to play a variety of roles in cellular function. A detailed ab initio electronic structure analysis of these thiols is reported evaluating the thermodynamics of the reactions of these intracellular thiols with alkyl thiols, HO., H2O2, ascorbate and their disulfides. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：1357 / 1360

页数：4

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