cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical Practice

被引：40

作者：

Chen, Bangjie ^{[1
]}

Rao, Xianyue ^{[1
]}

Wang, Xinyi ^{[2
]}

Luo, Zhipan ^{[1
]}

Wang, Jianpeng ^{[2
]}

Sheng, Shuyan ^{[2
]}

Liu, Yuchen ^{[1
]}

Zhang, Ning ^{[2
]}

Jin, Shiyu ^{[2
]}

Chen, Haosong ^{[2
]}

Sun, Chenyu ^{[3
]}

Xu, Tao ^{[4
,5
]}

Du, Yingying ^{[1
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China

[2] Anhui Med Univ, Clin Med Coll 1, Hefei, Peoples R China

[3] AMITA Hlth St Joseph Hosp, Chicago, IL USA

[4] Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Peoples R China

[5] Anhui Med Univ, Sch Pharm, Hefei, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

CGAS; STING; liver; inflammation; cancer; NF-KAPPA-B; VIRUS REPLICATION; INNATE IMMUNITY; DNA SENSOR; INFLAMMATION; CANCER; CELLS; ACTIVATION; INJURY; CONTRIBUTES;

D O I：

10.3389/fphar.2021.719644

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The cGAS-STING signaling pathway is an autoimmune inflammatory pathway that can trigger the expression of a series of inflammatory factors represented by type 1 interferon. Recent studies have found that the cGAS-STING signaling pathway played a significant role in liver physiology and was closely related to the progress of liver diseases. For example, activating the cGAS-STING signaling pathway could significantly inhibit hepatitis B virus (HBV) replication in vivo. Moreover, the cGAS-STING signaling pathway was also closely associated with tumor immunity in hepatocellular carcinoma (HCC). This review summarized the role of the cGAS-STING signaling pathway in several common liver diseases, especially the current application of the cGAS-STING signaling pathway in liver disease treatment, and prospected its future research, which provided a new idea for understanding and treating liver diseases.

引用

页数：11

共 88 条

[1]

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1 [J].