Failure to find P50 suppression deficits in young first-episode patients with schizophrenia and clinically unaffected siblings

被引：43

作者：

de Wilde, O. M.

Bour, L. J.

Dingemans, P. M.

Koelman, J. H. T. M.

Linszen, D. H.

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 BC Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Clin Neurophysiol, Dept Neurol, NL-1105 BC Amsterdam, Netherlands

来源：

SCHIZOPHRENIA BULLETIN | 2007年 / 33卷 / 06期

关键词：

early psychosis; neurophysiology; relatives; endophenotype;

D O I：

10.1093/schbul/sbm001

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To evaluate whether the P50 gating deficit is present in young first-episode patients with schizophrenia and their healthy young siblings. Methods: An auditory paired-click paradigm was used to assess P50 gating in 53 patients, 27 unaffected siblings, and 28 healthy controls. P50 parameters were compared between patients, sibs, and unrelated controls by a mixed-effects regression model. Results: P50 gating was not significantly impaired in patients with schizophrenia and healthy siblings as compared with controls. Conclusions: P50 gating was not found to be significantly impaired in young first-episode schizophrenia patients and in healthy young siblings. These results are in contrast with the existing literature. We suggest that P50 gating impairment may be developmentally or age dependent.

引用

页码：1319 / 1323

页数：5