Alterations in the expression of signal-transducing CD3ζ chain in T cells from patients with chronic inflammatory/autoimmune diseases

被引：19

作者：

Ciszak, Lidia ^{[1
]}

Pawlak, Edyta ^{[1
]}

Kosmaczewska, Agata ^{[1
]}

Potoczek, Stanislaw ^{[2
]}

Frydecka, Irena ^{[1
,2
]}

机构：

[1] Polish Acad Sci, Inst Immunol & Expt Therapy, Dept Expt Therapy, Immunopathol Lab, PL-53114 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Hematol, Wroclaw, Poland

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2007年 / 55卷 / 06期

关键词：

CD3 zeta chain; TCR/CD3; complex; chronic inflammatory diseases; autoimmune diseases; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RECEPTOR ZETA-CHAIN; IDIOPATHIC NEPHROTIC SYNDROME; RHEUMATOID-ARTHRITIS PATIENTS; SPLICED 3'-UNTRANSLATED REGION; SYNOVIAL-FLUID LYMPHOCYTES; PERIPHERAL-BLOOD LYMPHOCYTES; HIGH-AFFINITY RECEPTOR; TCR-ZETA; MESSENGER-RNA;

D O I：

10.1007/s00005-007-0042-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD3 zeta chain, a component of the T cell receptor (TCR)/CD3 complex, is considered to be a limiting factor in the assembly and transport of the TCR/CD3 complex to the cell surface and is crucial to receptor signaling function. Recent studies have demonstrated altered expression and function of this signal transduction molecule in T and natural killer cells in patients with chronic inflammatory/autoimmune diseases. In this review, current knowledge concerning the expression of CD3 zeta chain as well as the mechanisms responsible for abnormal expression of this molecule in systemic lupus erythematosus, rheumatoid arthritis, and childhood idiopathic nephrotic syndrome are summarized.

引用

页码：373 / 386

页数：14

共 118 条

[31]

HIROSE T, 1990, J RHEUMATOL, V17, P18

[32]

HOLD RC, 2002, CURR PEDIAT, V12, P551

[33] LYMPHOCYTE SUBPOPULATIONS, INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR EXPRESSION IN CHILDHOOD NEPHROTIC SYNDROME [J].

HULTON, SA ;

SHAH, V ;

BYRNE, MR ;

MORGAN, G ;

BARRATT, TM ;

DILLON, MJ .

PEDIATRIC NEPHROLOGY, 1994, 8 (02) :135-139

[34] Prolonged exposure of T cells to TNF down-regulates TCRζ and expression of the TCR/CD3 complex at the cell surface [J].

Isomäki, P ;

Panesar, M ;

Annenkov, A ;

Clark, JM ;

Foxwell, BMJ ;

Chernajovsky, Y ;

Cope, AP .

JOURNAL OF IMMUNOLOGY, 2001, 166 (09) :5495-5507

[35]

Isomaki Pia, 2005, Current Drug Targets - Inflammation and Allergy, V4, P287, DOI 10.2174/1568010054022042

[36]

JENSEN JP, 1992, J IMMUNOL, V148, P2563

[37] Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR ζ-chain in patients with systemic lupus erythematosus [J].

Juang, YT ;

Tenbrock, K ;

Nambiar, MP ;

Gourley, MF ;

Tsokos, GC .

JOURNAL OF IMMUNOLOGY, 2002, 169 (10) :6048-6055

[38] Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR ζ-chain [J].

Juang, YT ;

Solomou, EE ;

Rellahan, B ;

Tsokos, GC .

JOURNAL OF IMMUNOLOGY, 2002, 168 (06) :2865-2871

[39] Abnormal T cell signal transduction in systemic lupus erythematosus [J].

Kammer, GM ;

Perl, A ;

Richardson, BC ;

Tsokos, GC .

ARTHRITIS AND RHEUMATISM, 2002, 46 (05) :1139-1154

[40] Signal transduction by the TCR for antigen [J].

Kane, LP ;

Lin, J ;

Weiss, A .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (03) :242-249

← 1 2 3 4 5 6 7 8 9 10 →