Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins

被引：18

作者：

Gouin, SG

Pilgrim, W

Porter, RK ^{[1
]}

Murphy, PV

机构：

[1] Univ Coll Dublin, Dept Biochem, Dublin 2, Ireland

[2] Univ Coll Dublin, Ctr Synth & Chem Biol, Dept Chem, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland

来源：

CARBOHYDRATE RESEARCH | 2005年 / 340卷 / 08期

基金：

爱尔兰科学基金会;

关键词：

mitochondrial uncoupling protein; glycoconjugates; glucose-O-omega-palmitic acid; palmitic acid; 16-(beta-D-glucopyranosyloxy)-hexadecanoic acid;

D O I：

10.1016/j.carres.2005.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucose-O-omega-palmitic acid is an amphipathic molecule that is useful as a tool for studying the mechanism of mitochondrial uncoupling proteins. The synthesis of this glycolipid is described herein. The study of the reaction of a series of glycosyl donors with appropriate acceptors derived from 16-hydroxyhexadecanoic acid showed that a glycosyl trichloroacetimidate donor was more efficient than thioglycoside, glycosyl halide and glycosyl acetate donors for synthesis of this glycolipid. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1547 / 1552

页数：6