Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group

被引：38

作者：

Li, B ^{[1
]}

Bemish, R

Buzon, RA

Chiu, CKF

Colgan, ST

Kissel, W

Le, T

Leeman, KR

Newell, L

Roth, J

机构：

[1] Pfizer Global Res & Dev, Chem Res & Dev, Groton Labs, Groton, CT 06340 USA

[2] Pfizer Global Res & Dev, Chem Res & Dev, Holland, MI 49424 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 44期

关键词：

phosphoric acid; BOC; deprotection;

D O I：

10.1016/j.tetlet.2003.09.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aqueous phosphoric acid (85 wt%) is an efficient and mild reagent for the deprotection of N-BOC groups. Acid sensitive functionalities including benzyl and methyl esters, TBDMS ether, CBZ and isopropylidene groups are compatible with the reaction conditions. The reactions are high yielding, and the workup is convenient. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8113 / 8115

页数：3

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