Spatiotemporal control over growth factor signaling for therapeutic neovascularization

被引：100

作者：

Cao, Lan ^{[1
]}

Mooney, David J. ^{[1
]}

机构：

[1] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2007年 / 59卷 / 13期

关键词：

therapeutic neovascularization; angiogenesis; growth factor; temporal and spatial; quantitative; delivery system;

D O I：

10.1016/j.addr.2007.08.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Many of the qualitative roles of growth factors involved in neovascularization have been delineated, but it is unclear yet from an engineering perspective how to use these factors as therapies. We propose that an approach that integrates quantitative spatiotemporal measurements of growth factor signaling using 3-D in vitro and in vivo models, mathematic modeling of factor tissue distribution, and new delivery technologies may provide an opportunity to engineer neovascularization on demand. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：1340 / 1350

页数：11

共 163 条

[1] VASCULAR ENDOTHELIAL GROWTH-FACTOR ACTS AS A SURVIVAL FACTOR FOR NEWLY FORMED RETINAL-VESSELS AND HAS IMPLICATIONS FOR RETINOPATHY OF PREMATURITY [J].

ALON, T ;

HEMO, I ;

ITIN, A ;

PEER, J ;

STONE, J ;

KESHET, E .

NATURE MEDICINE, 1995, 1 (10) :1024-1028

[2] Quantitative method to study the network formation of endothelial cells in response to tumor angiogenic factors [J].

Amyot, F ;

Camphausen, K ;

Siavosh, A ;

Sackett, D ;

Gandjbakhche, A .

IEE PROCEEDINGS SYSTEMS BIOLOGY, 2005, 152 (02) :61-66

[3] VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells [J].

Asahara, T ;

Takahashi, T ;

Masuda, H ;

Kalka, C ;

Chen, DH ;

Iwaguro, H ;

Inai, Y ;

Silver, M ;

Isner, JM .

EMBO JOURNAL, 1999, 18 (14) :3964-3972

[4] Angiogenesis assays: A critical overview [J].

Auerbach, R ;

Lewis, R ;

Shinners, B ;

Kubai, L ;

Akhtar, N .

CLINICAL CHEMISTRY, 2003, 49 (01) :32-40

[5] Alginate hydrogels as biomaterials [J].

Augst, Alexander D. ;

Kong, Hyun Joon ;

Mooney, David J. .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (08) :623-633

[6] DIFFERENTIAL EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR (VASCULAR-PERMEABILITY FACTOR) FORMS IN RAT-TISSUES [J].

BACIC, M ;

EDWARDS, NA ;

MERRILL, MJ .

GROWTH FACTORS, 1995, 12 (01) :11-15

[7] Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal [J].

Benjamin, LE ;

Keshet, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8761-8766

[8] Effect of well defined dodecahedral porosity on inflammation and angiogenesis [J].

Bezuidenhout, D ;

Davies, N ;

Zilla, P .

ASAIO JOURNAL, 2002, 48 (05) :465-471

[9] Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution [J].

Boontheekul, T ;

Kong, HJ ;

Mooney, DJ .

BIOMATERIALS, 2005, 26 (15) :2455-2465

[10] Therapeutic neovascularization: Contributions from bioengineering [J].

Brey, EM ;

Uriel, S ;

Greisler, HP ;

Patrick, CW ;

McIntire, LV .

TISSUE ENGINEERING, 2005, 11 (3-4) :567-584

← 1 2 3 4 5 6 7 8 9 10 →