Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele

被引：29

作者：

Dorado, P. ^{[1
]}

Penas-Lledo, E. M. ^{[1
]}

Gonzalez, A. P. ^{[1
]}

Caceres, M. C. ^{[1
]}

Cobaleda, J. ^{[1
]}

LLerena, A. ^{[1
]}

机构：

[1] Univ Extremadura, Sch Med, Univ Hosp, Clin Res Ctr CICAB Serv Extremeno SAlud, Badajoz, Spain

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2007年 / 21卷 / 04期

关键词：

CYP2C9; genetic polymorphism; 5-HTTLPR; major depression; serotonin;

D O I：

10.1111/j.1472-8206.2007.00501.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study, we aimed to analyze the potential relevance of the polymorphism in the promoter region of the serotonin transporter (SERT or 5-HTT) gene (5-HTTLPR) and the risk of suffering major depression (MDD) in a population of patients previously genotyped for CYP2C9. Seventy white European psychiatric outpatients suffering from MDD and a group of 142 healthy volunteers (HVs) were studied. The frequency of subjects carrying the 5-HTTLPR-S allele was higher (P < 0.05) among MDD than in HV. The odds ratio associated with 5-HTTLPR-S allele was 2.03 for the MDD patients in comparison with the HV group. Previously, we found in this population that the CYP2C9*3 allele frequency was higher among this population of MDD patients than in HV. The frequency of subjects with the combination 5-HTTLPR-S and CYP2C9*3 alleles was higher (P < 0.01, odds ratio 3.47) in MDD than in HV. The present findings provide preliminary evidence about the greater risk of suffering MDD for individuals carrying both 5-HTTLPR-S and CYP2C9*3 alleles.

引用

页码：451 / 453

页数：3

共 21 条

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