Vaccinia virus recombinant expressing an 87-kilodalton polyprotein that is sufficient to form astrovirus-like particles

被引：15

作者：

Dalton, RM ^{[1
]}

Pastrana, EP ^{[1
]}

Sánchez-Fauquier, A ^{[1
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid 28220, Spain

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 16期

关键词：

D O I：

10.1128/JVI.77.16.9094-9098.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human astrovirus is an important cause of acute gastroenteritis. We have generated, for the first time, a vaccinia virus recombinant expressing the astrovirus 87-kDa structural polyprotein. The results demonstrate that this expression results in the formation of virus-like particles in the absence of other astrovirus proteins and genomic RNA. The purified trypsin-activated virus-like particles strongly resemble the complete astrovirus particles.

引用

页码：9094 / 9098

页数：5

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