Research Review: Genetic vulnerability or differential susceptibility in child development: the case of attachment

被引：172

作者：

Bakermans-Kranenburg, Marian J. ^{[1
]}

van IJzendoorn, Marinus H. ^{[1
]}

机构：

[1] Leiden Univ, Ctr Family & Child Studies, NL-2300 RB Leiden, Netherlands

来源：

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY | 2007年 / 48卷 / 12期

关键词：

attachment; gene-environment interaction; differential susceptibility; disorganized attachment; dopamine; behavior problems; genetics;

D O I：

10.1111/j.1469-7610.2007.01801.x

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Gene-environment interactions interpreted in terms of differential susceptibility may play a large part in the explanation of individual differences in human development. Reviewing studies on the behavioral and molecular genetics of attachment, we present evidence for interactions between genetic and environmental factors explaining individual differences in attachment security and disorganization. In particular, the DRD4 7-repeat polymorphism seems associated with an increased risk for disorganized attachment, but only when combined with environmental risk. Gene-environment (G x E) interactions may be interpreted as genetic vulnerability or differential susceptibility. We found support for the differential susceptibility hypothesis predicting not only more negative outcomes for susceptible children in unfavorable environments, but also positive outcomes for susceptible children in favorable environments.

引用

页码：1160 / 1173

页数：14

共 116 条

[51] Harris JudithRich., 1998, NURTURE ASSUMPTION
[52] Frightened, threatening, and dissociative parental behavior in low-risk samples: Description, discussion, and interpretations
Hesse, E
Main, M
[J]. DEVELOPMENT AND PSYCHOPATHOLOGY, 2006, 18 (02) : 309 - 343
[53] Hesse E., 1999, HDB ATTACHMENT, P395, DOI DOI 10.1016S0191-8869(02)00333-1
[54] HINDE RA, 1988, RELATIONSHIPS FAMILI
[55] Genetic associations: false or true?
Ioannidis, JPA
[J]. TRENDS IN MOLECULAR MEDICINE, 2003, 9 (04) : 135 - 138
[56] Does expectant mothers' unresolved trauma predict frightened/frightening maternal behavior? Risk and protective factors
Jacobvitz, D
Leon, K
Hazen, N
[J]. DEVELOPMENT AND PSYCHOPATHOLOGY, 2006, 18 (02) : 363 - 379
[57] Nature X nurture: Genetic vulnerabilities interact with physical maltreatment to promote conduct problems
Jaffee, SR
Caspi, A
Moffitt, TE
Dodge, KA
Rutter, M
Taylor, A
Tully, LA
[J]. DEVELOPMENT AND PSYCHOPATHOLOGY, 2005, 17 (01) : 67 - 84
[58] Twin study of dissociative experience
Jang, KL
Paris, J
Zweig-Frank, H
Livesley, WJ
[J]. JOURNAL OF NERVOUS AND MENTAL DISEASE, 1998, 186 (06) : 345 - 351
[59] Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman, J
Yang, BZ
Douglas-Palumberi, H
Houshyar, S
Lipschitz, D
Krystal, JH
Gelernter, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) : 17316 - 17321
[60] MAOA, maltreatment, and gene-environment interaction predicting children's mental health:: new evidence and a meta-analysis
Kim-Cohen, J.
Caspi, A.
Taylor, A.
Williams, B.
Newcombe, R.
Craig, I. W.
Moffitt, T. E.
[J]. MOLECULAR PSYCHIATRY, 2006, 11 (10) : 903 - 913

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