Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)

被引：367

作者：

Dayyani, Farshid ^{[1
,2
]}

Etzel, Carol J. ^{[3
]}

Liu, Mei ^{[3
]}

Ho, Chung-Han ^{[3
]}

Lippman, Scott M. ^{[1
]}

Tsao, Anne S. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

来源：

HEAD & NECK ONCOLOGY | 2010年 / 2卷

关键词：

P16(INK4A) EXPRESSION; TONSILLAR CARCINOMAS; P16; PROTEIN; INFECTION; SUBSET; ASSOCIATION; PROGNOSIS; PROFILES; ETIOLOGY; TYPE-18;

D O I：

10.1186/1758-3284-2-15

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: HPV is important in a subset of HNSCC. Our meta-analysis determined the clinical characteristics of HPV-related HNSCC. Method: Pubmed search terms "HPV" and "HNSCC" were used to identify 34 studies since 1980. We obtained pooled adjusted odds ratio ( OR) or hazard ratio (HR) using random or fixed-effects model and compared OS depicted in forest plot. Results: A total of 5681 patients were included. The prevalence of HPV+ tumors was 22%, with 86.7% of HPV16+ genotype. The OR for HNSCC in HPV16+ patients was 4.44 (95% CI = 2.87-6.02). HPV status was associated with p16 expression (adj OR = 3.00; 0.90-9.70), and HPV+ tumors were less likely to harbor p53 mutations ( adj OR = 0.21; 0.04-0.38). The HR for death in HPV+ patients was 0.42 (0.27-0.57). HPV+ HNSCC also had a better response to therapy. Conclusion: HPV+ HNSCC are established as a separate biologic entity. Prospective trials are needed to establish the optimal therapy for HPV+ HNSCC.

引用

页数：11

共 49 条

[21] Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review [J].

Kreimer, AR ;

Clifford, GM ;

Boyle, P ;

Franceschi, S .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (02) :467-475

[22] EGFR, p16, HPV titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer [J].

Kumar, Bhavna ;

Cordell, Kitrina G. ;

Lee, Julia S. ;

Worden, Francis P. ;

Prince, Mark E. ;

Tran, Huong H. ;

Wolf, Gregory T. ;

Urba, Susan G. ;

Chepeha, Douglas B. ;

Teknos, Theodoros N. ;

Eisbruch, Avraham ;

Tsien, Christina I. ;

Taylor, Jeremy M. G. ;

D'Silva, Nisha J. ;

Yang, Kun ;

Kurnit, David M. ;

Bauer, Joshua A. ;

Bradford, Carol R. ;

Carey, Thomas E. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (19) :3128-3137

[23] Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking [J].

Kumar, Bhavna ;

Cordell, Kitrina G. ;

Lee, Julia S. ;

Prince, Mark E. ;

Tran, Huong H. ;

Wolf, Gregory T. ;

Urba, Susan G. ;

Worden, Francis P. ;

Chepeha, Douglas B. ;

Teknos, Theodoros N. ;

Eisbruch, Avraham ;

Tsien, Christina I. ;

Taylor, Jeremy M. G. ;

D'Silva, Nisha J. ;

Yang, Kun ;

Kurnit, David M. ;

Bradford, Carol R. ;

Carey, Thomas E. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (02) :S109-S111

[24] Effect of HPV-Associated p16INK4A Expression on Response to Radiotherapy and Survival in Squamous Cell Carcinoma of the Head and Neck [J].

Lassen, Pernille ;

Eriksen, Jesper G. ;

Hamilton-Dutoit, Stephen ;

Tramm, Trine ;

Alsner, Jan ;

Overgaard, Jens .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (12) :1992-1998

[25] The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil [J].

Li, W ;

Thompson, CH ;

Cossart, YE ;

O'Brien, CJ ;

McNeil, EB ;

Scolyer, RA ;

Rose, BR .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2004, 26 (01) :1-9

[26]

LI Y, 1994, CANCER RES, V54, P6078

[27] High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma [J].

Licitra, Lisa ;

Perrone, Federica ;

Bossi, Paolo ;

Suardi, Simona ;

Mariani, Luigi ;

Artusi, Raffaella ;

Oggionni, Maria ;

Rossini, Chiara ;

Cantu, Giulio ;

Squadrelli, Massimo ;

Quattrone, Pasquale ;

Locati, Laura D. ;

Bergamini, Cristiana ;

Olmi, Patrizia ;

Pierotti, Marco A. ;

Pilotti, Silvana .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (36) :5630-5636

[28] COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells [J].

Mroz, Edmund A. ;

Baird, Abigail H. ;

Michaud, William A. ;

Rocco, James W. .

CANCER RESEARCH, 2008, 68 (15) :6049-6053

[29]

Murata M, 1996, CANCER DETECT PREV, V20, P557

[30] HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma [J].

Nichols, Anthony C. ;

Faquin, William C. ;

Westra, William H. ;

Mroz, Edmund A. ;

Begum, Shanaz ;

Clark, John R. ;

Rocco, James W. .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2009, 140 (02) :228-234

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