Lycopene in Cancer Prevention and Treatment

被引：59

作者：

Seren, Soley ^{[2
,3
]}

Lieberman, Ronald ^{[4
]}

Bayraktar, Ulas D. ^{[1
,3
]}

Heath, Elisabeth ^{[1
,2
,3
]}

Sahin, Kazim ^{[5
]}

Andic, Fundagul

Kucuk, Omer ^{[1
,2
,3
]}

机构：

[1] Wayne State Univ, Div Hematol & Oncol, Detroit, MI 48201 USA

[2] Wayne State Univ, Dept Internal Med, Detroit, MI 48201 USA

[3] Barbara Ann Karmanos Canc Inst, Detroit, MI USA

[4] MedImmune, Gaithersburg, MD USA

[5] Firat Univ, Fac Vet Sci, Dept Anim Nutr, TR-23169 Elazig, Turkey

来源：

AMERICAN JOURNAL OF THERAPEUTICS | 2008年 / 15卷 / 01期

关键词：

lycopene; cancer; clinical trials; carotenoid compounds;

D O I：

10.1097/MJT.0b013e31804c7120

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dietary intake of lycopene is inversely associated with the risk of many cancers. Preclinical studies show that lycopene has potent in vitro and in vivo antitumor effects, suggesting potential preventive and therapeutic roles for the compound. However, clinical trials with lycopene have only recently been started, and available clinical data preclude firm conclusions with regard to its use in cancer prevention and treatment. Further mechanistic studies and randomized controlled clinical intervention trials with lycopene involving cancer patients are warranted.

引用

页码：66 / 81

页数：16

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