Glycosylation of IgA1 and pathogenesis of IgA nephropathy

被引：117

作者：

Novak, Jan ^{[1
]}

Julian, Bruce A. ^{[1
]}

Mestecky, Jiri ^{[1
]}

Renfrow, Matthew B. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2012年 / 34卷 / 03期

基金：

美国国家卫生研究院;

关键词：

IgA nephropathy; IgA1; O-glycans; High-resolution mass spectrometry; Measangial cells; HUMAN MESANGIAL CELLS; ELECTRON-CAPTURE DISSOCIATION; FLIGHT MASS-SPECTROMETRY; HUMAN SERUM IGA1; O-LINKED OLIGOSACCHARIDES; HENOCH-SCHONLEIN PURPURA; GALACTOSE-DEFICIENT IGA1; HUMAN COLONIC MUCIN; IGA1-CONTAINING IMMUNE-COMPLEXES; IMMUNOGLOBULIN-A NEPHROPATHY;

D O I：

10.1007/s00281-012-0306-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune disease. Galactose-deficient IgA1 is recognized by unique autoantibodies, resulting in the formation of pathogenic immune complexes that ultimately induce glomerular injury. Thus, formation of the galactose-deficient IgA1-containing immune complexes is a critical factor in the pathogenesis of IgA nephropathy. Studies of molecular defects of IgA1 can define new biomarkers specific for IgA nephropathy that can be developed into clinical assays to aid in the diagnosis, assessment of prognosis, and monitoring of disease progression.

引用

页码：365 / 382

页数：18

共 180 条

[81]

KIRYLUK K, 2010, PEDIATR NEPHROL, V25, P2257, DOI DOI 10.1007/S00467-010-1500-7

[82] Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schonlein purpura nephritis [J].

Kiryluk, Krzysztof ;

Moldoveanu, Zina ;

Sanders, John T. ;

Eison, T. Matthew ;

Suzuki, Hitoshi ;

Julian, Bruce A. ;

Novak, Jan ;

Gharavi, Ali G. ;

Wyatt, Robert J. .

KIDNEY INTERNATIONAL, 2011, 80 (01) :79-87

[83]

Kohlgraf KG, 2003, CANCER RES, V63, P5011

[84] Exposed peptide core of IgA1 hinge region in IgA nephropathy [J].

Kokubo, T ;

Hiki, Y ;

Iwase, H ;

Tanaka, A ;

Nishikido, J ;

Hotta, K ;

Kobayashi, Y .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (01) :81-85

[85] Redefined substrate specificity of ST6Ga1NAc II: A second candidate sialyl-Tn synthase [J].

Kono, M ;

Tsuda, T ;

Ogata, S ;

Takashima, S ;

Liu, H ;

Hamamoto, T ;

Itzkowitz, SH ;

Nishimura, S ;

Tsuji, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 272 (01) :94-97

[86]

KUTTEH WH, 1982, GASTROENTEROLOGY, V82, P184

[87] Activation of podocytes by mesangial-derived TNF-α:: glomerulo-podocytic communication in IgA nephropathy [J].

Lai, Kar Neng ;

Leung, Joseph C. K. ;

Chan, Loretta Y. Y. ;

Saleem, Moin A. ;

Mathieson, Peter W. ;

Lai, Fernand M. ;

Tang, Sydney C. W. .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 294 (04) :F945-F955

[88] Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy [J].

Lai, Kar Neng ;

Leung, Joseph C. K. ;

Chan, Loretta Y. Y. ;

Saleem, Moin A. ;

Mathieson, Peter W. ;

Tam, Ka Ying ;

Xiao, Jing ;

Lai, Fernand M. ;

Tang, Sydney C. W. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (01) :62-72

[89]

LAMONT JT, 1980, BIOCHIM BIOPHYS ACTA, V626, P234

[90] Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schonlein purpura [J].

Lau, Keith K. ;

Wyatt, Robert J. ;

Moldoveanu, Zina ;

Tomana, Milan ;

Julian, Bruce A. ;

Hogg, Ronald J. ;

Lee, Jeannette Y. ;

Huang, Wen-Qiang ;

Mestecky, Jiri ;

Novak, Jan .

PEDIATRIC NEPHROLOGY, 2007, 22 (12) :2067-2072

← 4 5 6 7 8 9 10 11 12 13 →