Unifying themes in host defence effector polypeptides

被引：162

作者：

Yeaman, Michael R. ^{[1
]}

Yount, Nannette Y.

机构：

[1] Harbor UCLA Med Ctr, LAC, Div Infect Dis, Torrance, CA 90509 USA

[2] Univ Calif Los Angeles, St Johns Cardiovasc Res Ctr, Inst Biomed Res, Torrance, CA 90502 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90024 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 09期

关键词：

D O I：

10.1038/nrmicro1744

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It is said that nature is the greatest innovator, yet molecular conservation can be equally powerful. One key requirement for the survival of any host is its ability to defend against infection, predation and competition. Recent discoveries, including the presence of a multidimensional structural signature, have revealed a previously unforeseen structural and functional congruence among host defence effector molecules spanning all kingdoms of life. Antimicrobial peptides, kinocidins, polypeptide venoms and other molecules that were once thought to be distinct in form and function now appear to be members of an ancient family of host defence effectors. These molecules probably descended from archetype predecessors that emerged during the beginning of life on earth. Understanding how nature has sustained these host defence molecules with a potent efficacy in the face of dynamic microbial evolution should provide new opportunities to prevent or treat life-threatening infections.

引用

页码：727 / 740

页数：14

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