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Opinion - Survivin, cancer networks and pathway-directed drug discovery

被引：856
作者：
Altieri, Dario C. [1 ,2 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01605 USA
[2] Univ Massachusetts, Sch Med, Ctr Canc, Worcester, MA 01605 USA
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 01期
关键词：
D O I：
10.1038/nrc2293
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although there is no shortage of potential targets for cancer therapeutics, we know of only a handful of molecules that are differentially expressed in cancer and intersect multiple pathways required for tumour maintenance. Survivin embodies these properties, and orchestrates integrated cellular networks that are essential for tumour cell proliferation and viability. Pursuing the nodal functions of survivin in cancer might lead to the development of global pathway inhibitors with unique therapeutic potential.
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页码：61 / 70
页数：11
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