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Curing metastatic cancer:: Lessons from testicular germ-cell tumours

被引：175
作者：
Masters, JRW
Köberle, B
机构：
[1] UCL, Inst Urol, Prostate Canc Res Ctr, London W1W 7EJ, England
[2] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Pittsburgh, PA 15213 USA
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 07期
关键词：
D O I：
10.1038/nrc1120
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Most metastatic cancers are fatal. More than 80% of patients with metastatic testicular germ-cell tumours (TGCTs), however, can be cured using cisplatin-based combination chemotherapy. Why are TGCTs more sensitive to chemotherapeutics than most other tumour types? Answers to this question could lead to new treatments for metastatic cancers.
引用
收藏
页码：517 / 525
页数：9
相关论文
共 80 条
  • [51] Mueller T, 2003, CANCER RES, V63, P513
  • [52] OCONNOR PM, 1997, CANCER RES, V57, P4825
  • [53] Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins
    Ohndorf, UM
    Rould, MA
    He, Q
    Pabo, CO
    Lippard, SJ
    [J]. NATURE, 1999, 399 (6737) : 708 - 712
  • [54] Binding of tsHMG, a mouse testis-specific HMG-domain protein, to cisplatin-DNA adducts
    Ohndorf, UM
    Whitehead, JP
    Raju, NL
    Lippard, SJ
    [J]. BIOCHEMISTRY, 1997, 36 (48) : 14807 - 14815
  • [55] Apoptosis of human seminoma cells upon disruption of their microenvironment
    Olie, RA
    Boersma, AWM
    Dekker, MC
    Nooter, K
    Looijenga, LHJ
    Oosterhuis, JW
    [J]. BRITISH JOURNAL OF CANCER, 1996, 73 (09) : 1031 - 1036
  • [56] EFFECTS OF CIS-PLATINUM ON EMBRYONAL CARCINOMA CELL-LINES INVITRO
    OOSTERHUIS, JW
    ANDREWS, PW
    KNOWLES, BB
    DAMJANOV, I
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1984, 34 (01) : 133 - 139
  • [57] Estimating the world cancer burden: GLOBOCAN 2000
    Parkin, DM
    Bray, F
    Ferlay, J
    Pisani, P
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2001, 94 (02) : 153 - 156
  • [58] PARRIS CN, 1990, CANCER RES, V50, P7513
  • [59] DIFFERENTIAL SENSITIVITIES TO GAMMA-RADIATION OF HUMAN BLADDER AND TESTICULAR-TUMOR CELL-LINES
    PARRIS, CN
    ARLETT, CF
    LEHMANN, AR
    GREEN, MHL
    MASTERS, JRW
    [J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1988, 53 (04) : 599 - 608
  • [60] PERA MF, 1987, CANCER RES, V47, P6810
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