Locked nucleic acid-nanoparticle conjugates

被引：67

作者：

Seferos, Dwight S.

Giljohann, David A.

Rosi, Nathaniel L.

Mirkin, Chad A.

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 11期

关键词：

ULTRASENSITIVE DETECTION; CARBON NANOTUBES; DNA; BINDING; POLYNUCLEOTIDES; NANOWIRES; MOLECULES; APOPTOSIS; SURVIVIN; DELIVERY;

D O I：

10.1002/cbic.200700262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) Designer nanoparticle conjugates. Locked nucleic acid (LNA) oligonucleotides can be used to functionalize nanoparticles to yield a novel conjugate that is highly stable and has a remarkably high affinity for complementary nucleic acids. When tested in a cell line model, these conjugates were found to be effective at controlling survivin gene expression. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1230 / 1232

页数：3

共 37 条

[1] Transcription inhibition using oligonucleotide-modified gold nanoparticles
Agbasi-Porter, Chiamaka
Ryman-Rasmussen, Jessica
Franzen, Stefan
Feldheim, Daniel
[J]. BIOCONJUGATE CHEMISTRY, 2006, 17 (05) : 1178 - 1183
[2] Organization of 'nanocrystal molecules' using DNA
Alivisatos, AP
Johnsson, KP
Peng, XG
Wilson, TE
Loweth, CJ
Bruchez, MP
Schultz, PG
[J]. NATURE, 1996, 382 (6592) : 609 - 611
[3] Survivin, versatile modulation of cell division and apoptosis in cancer
Altieri, DC
[J]. ONCOGENE, 2003, 22 (53) : 8581 - 8589
[4] [Anonymous], ANGEW CHEM, DOI DOI 10.1002/ANGE.200600214
[5] [Anonymous], ANGEW CHEM
[6] Nanocrystals modified with peptide nucleic acids (PNAs) for selective self-assembly and DNA detection
Chakrabarti, R
Klibanov, AM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (41) : 12531 - 12540
[7] Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
Chithrani, BD
Ghazani, AA
Chan, WCW
[J]. NANO LETTERS, 2006, 6 (04) : 662 - 668
[8] Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles
Elghanian, R
Storhoff, JJ
Mucic, RC
Letsinger, RL
Mirkin, CA
[J]. SCIENCE, 1997, 277 (5329) : 1078 - 1081
[9] Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles
Han, Gang
You, Chang-Cheng
Kim, Byoung-Jin
Turingan, Rosemary S.
Forbes, Neil S.
Martin, Craig T.
Rotello, Vincent M.
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (19) : 3165 - 3169
[10] Colorimetric screening of DNA-binding molecules with gold nanoparticle probes
Han, MS
Lytton-Jean, AKR
Oh, BK
Heo, J
Mirkin, CA
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (11) : 1807 - 1810

← 1 2 3 4 →