Complement-inhibiting cucurbitacin glycosides from Picria fel-terrae

被引：34

作者：

Huang, Y ^{[1
]}

De Bruyne, T ^{[1
]}

Apers, S ^{[1
]}

Ma, YL ^{[1
]}

Claeys, M ^{[1
]}

Vanden Berghe, D ^{[1
]}

Pieters, L ^{[1
]}

Vlietinck, A ^{[1
]}

机构：

[1] Univ Instelling Antwerp, Dept Pharmaceut Sci, B-2610 Wilrijk, Belgium

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 06期

关键词：

D O I：

10.1021/np9705773

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four cucurbitacin glycosides were isolated from Picria fel-terrae and identified by MS and NMR spectroscopy as picfeltarraenin IA (1), picfeltarraenin IB (2), picfeltarraenin IV (4), and a new compound picfeltarraenin VI (3) (picfeltarraegenin I 3-O-beta-D-xylopyranoside). All four compounds acted as inhibitors on both the classical and alternative pathways of the complement system, with compound 3 exhibiting the highest inhibitory activity (IC50 29 +/- 2 mu M and 21 +/- 1 mu M, respectively). Compounds 1-4 showed no antiviral, antibacterial, or antifungal activities. Picfeltarraenin IA and IB were tested in an in vitro human tumor cell line panel, but displayed no cytotoxic activity.

引用

页码：757 / 761

页数：5

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