Preparation and characterization of chitosan-polylactide composites blended with Cloisite 30B for control release of the anticancer drug paclitaxel

被引：78

作者：

Nanda, Rajashree ^{[1
]}

Sasmal, Abhisek ^{[1
]}

Nayak, P. L. ^{[1
]}

机构：

[1] PL Nayak Res Fdn, Cuttack 753006, Orissa, India

来源：

CARBOHYDRATE POLYMERS | 2011年 / 83卷 / 02期

关键词：

Biodegradable polymers; Anticancer drug; Drug delivery; Kinetics; POLY(L-LACTIC ACID); CREMOPHOR-EL; NANOCOMPOSITE HYDROGELS; POLYMER BLENDS; RAT-HEART; DELIVERY; MONTMORILLONITE; DEGRADATION; MATRICES; BEHAVIOR;

D O I：

10.1016/j.carbpol.2010.09.009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chitosan (CS) and polylactide (PLA) at different ratios were blended with different wt% of montmorillonite (MMT) (Cloisite 30B) solution by the solvent evaporation method MMT was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation Paclitaxel (PTX) with different concentrations was loaded with CS-PLA/MMT nanocomposites for studying in vitro drug delivery systems The composites were characterized by FTIR SEM and XRD methods The drug release was studied as a function of pH and drug concentrations The kinetics of the drug release was studied in order to ascertain the type of release mechanism Based on the diffusion as well as the kinetics the mechanism of the drug release from the composite matrix has been reported (C) 2010 Elsevier Ltd All rights reserved

引用

页码：988 / 994

页数：7

共 69 条

[1] Chemical compatibility study of geomembranes - sorption/desorption, diffusion and swelling phenomena [J].