Chromatin assembly during S phase: contributions from histone deposition, DNA replication and the cell division cycle

被引:48
作者
Krude, T [1 ]
Keller, C [1 ]
机构
[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
关键词
DNA replication; chromatin assembly; histone; nucleosome; protein kinase;
D O I
10.1007/PL00000890
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During S phase of the eukaryotic cell division cycle, newly replicated DNA is rapidly assembled into chromatin. Newly synthesised histones form complexes with chromatin assembly factors, mediating their deposition onto nascent DNA and their assembly into nucleosomes. Chromatin assembly factor 1, CAF-1, is a specialised assembly factor that targets these histones to replicating DNA by association with the replication fork associated protein, proliferating cell nuclear antigen, PCNA. Nucleosomes are further organised into ordered arrays along the DNA by the activity of ATP-dependent chromatin assembly and spacing factors such as ATP-utilising chromatin assembly and remodelling factor ACE An additional level of controlling chromatin assembly pathways has become apparent by the observation of functional requirements for cyclin-dependent protein kinases, casein kinase II and protein phosphatases. In this review, we will discuss replication-associated histone deposition and nucleosome assembly pathways, and we will focus in particular on how nucleosome assembly is linked to DNA replication and how it may be regulated by the cell cycle control machinery.
引用
收藏
页码:665 / 672
页数:8
相关论文
共 77 条
  • [51] HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins
    Poot, RA
    Dellaire, G
    Hülsmann, BB
    Grimaldi, MA
    Corona, DFV
    Becker, PB
    Bickmore, WA
    Varga-Weisz, PD
    [J]. EMBO JOURNAL, 2000, 19 (13) : 3377 - 3387
  • [52] Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins
    Qian, ZJ
    Huang, HH
    Hong, JY
    Burck, CL
    Johnston, SD
    Berman, J
    Carol, A
    Liebman, SW
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (08) : 4783 - 4792
  • [53] Quintini G, 1996, MOL CELL BIOL, V16, P2888
  • [54] Ridgway P, 2000, J CELL SCI, V113, P2647
  • [55] Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone
    Rodriguez, P
    Munroe, D
    Prawitt, D
    Chu, LL
    Bric, E
    Kim, J
    Reid, LH
    Davies, C
    Nakagama, H
    Loebbert, R
    Winterpacht, A
    Petruzzi, MJ
    Higgins, MJ
    Nowak, N
    Evans, G
    Shows, T
    Weissman, BE
    Zabel, B
    Housman, DE
    Pelletier, J
    [J]. GENOMICS, 1997, 44 (03) : 253 - 265
  • [56] NAP-2: Histone chaperone function and phosphorylation state through the cell cycle
    Rodriguez, P
    Pelletier, J
    Price, GB
    Zannis-Hadjopoulos, M
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 298 (02) : 225 - 238
  • [57] Histone acetylation and chromatin assembly: A single escort, multiple dances?
    Roth, SY
    Allis, CD
    [J]. CELL, 1996, 87 (01) : 5 - 8
  • [58] Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin
    Shibahara, K
    Stillman, B
    [J]. CELL, 1999, 96 (04) : 575 - 585
  • [59] The N-terminal domains of histones H3 and H4 are not necessary for chromatin assembly factor-1-mediated nucleosome assembly onto replicated DNA in vitro
    Shibahara, K
    Verreault, A
    Stillman, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) : 7766 - 7771
  • [60] MOLECULAR CHARACTERIZATION OF HNRP, A CDNA-ENCODING A HUMAN NUCLEOSOME-ASSEMBLY-PROTEIN-I-RELATED GENE-PRODUCT INVOLVED IN THE INDUCTION OF CELL-PROLIFERATION
    SIMON, HU
    MILLS, GB
    KOZLOWSKI, M
    HOGG, D
    BRANCH, D
    ISHIMI, Y
    SIMINOVITCH, KA
    [J]. BIOCHEMICAL JOURNAL, 1994, 297 : 389 - 397