Combined Deletions of pfhrp2 and pfhrp3 Genes Result in Plasmodium falciparum Malaria False-Negative Rapid Diagnostic Test

被引：65

作者：

Houze, Sandrine ^{[1
,2
,3
]}

Hubert, Veronique ^{[1
,2
,3
]}

Le Pessec, Gaelle ^{[1
]}

Le Bras, Jacques ^{[1
,2
,3
]}

Clain, Jerome ^{[2
,3
]}

机构：

[1] Hop Bichat Claude Bernard, AP HP, Parasitol Lab, F-75877 Paris 18, France

[2] Univ Paris 05, UMR 216, F-75006 Paris, France

[3] Inst Rech Dev, UMR 216, F-75006 Paris, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 07期

关键词：

SEQUENCE VARIATION; PERFORMANCE; DIVERSITY; VIVAX;

D O I：

10.1128/JCM.00281-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a case of misdiagnosis of Plasmodium falciparum malaria from Brazil with negative PfHRP2-based rapid diagnostic tests (RDTs), leading to inappropriate case management. Genetic tests showed the deletion of both pfhrp2 and pfhrp3 genes. The detection of two distinct P. falciparum target antigens is then advisable.

引用

页码：2694 / 2696

页数：3

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