Making sense of hematopoietic stem cell niches

被引:320
作者
Boulais, Philip E. [1 ,2 ]
Frenette, Paul S. [1 ,3 ]
机构
[1] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA
基金
美国国家卫生研究院;
关键词
BONE-MARROW; PROGENITOR CELLS; SELF-RENEWAL; N-CADHERIN; OSTEOBLASTIC CELLS; ENDOTHELIAL-CELLS; MAINTENANCE; QUIESCENCE; SUPPORT; HOMEOSTASIS;
D O I
10.1182/blood-2014-09-570192
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and proliferation. Anatomic localization of the niche is a dynamic unit from the developmental stage that allows proliferating HSCs to expand before they reach the bone marrow where they adopt a quiescent phenotype that protects their integrity and functions. Recent studies have sought to clarify the complexity behind the HSC niche by assessing the contributions of specific cell populations to HSC maintenance. In particular, perivascular microenvironments in the bone marrow confer distinct vascular niches that regulate HSC quiescence and the supply of lineage-committed progenitors. Here, we review recent data on the cellular constituents and molecular mechanisms involved in the communication between HSCs and putative niches.
引用
收藏
页码:2621 / 2629
页数:9
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