学术探索
学术期刊
新闻热点
数据分析
智能评审

The ETS-domain transcription factor family

被引：838
作者：
Sharrocks, AD [1 ]
机构：
[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 11期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1038/35099076
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
ETS-domain transcription-factor networks represent a model for how combinatorial gene expression is achieved. These transcription factors interact with a multitude of co-regulatory partners to elicit gene-specific responses and drive distinct biological processes. These proteins are controlled by a complex series of inter and intramolecular interactions, and signalling pathways impinge on these proteins to further regulate their action.
引用
收藏
页码：827 / 837
页数：11
相关论文
共 112 条
  • [51] Regulation of Ets function by protein-protein interactions
    Li, RZ
    Pei, HP
    Watson, DK
    [J]. ONCOGENE, 2000, 19 (55) : 6514 - 6523
  • [52] SOLUTION STRUCTURE OF THE ETS DOMAIN OF FLI-1 WHEN BOUND TO DNA
    LIANG, H
    MAO, XH
    OLEJNICZAK, ET
    NETTESHEIM, DG
    YU, LP
    MEADOWS, RP
    THOMPSON, CB
    FESIK, SW
    [J]. NATURE STRUCTURAL BIOLOGY, 1994, 1 (12): : 871 - 876
  • [53] DNA-BINDING BY C-ETS-1, BUT NOT V-ETS, IS REPRESSED BY AN INTRAMOLECULAR MECHANISM
    LIM, F
    KRAUT, N
    FRAMPTON, J
    GRAF, T
    [J]. EMBO JOURNAL, 1992, 11 (02) : 643 - 652
  • [54] Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
    Lin, JH
    Saito, T
    Anderson, DJ
    Lance-Jones, C
    Jessell, TM
    Arber, S
    [J]. CELL, 1998, 95 (03) : 393 - 407
  • [55] Net (ERP/SAP2), one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif
    Maira, SM
    Wurtz, JM
    Wasylyk, B
    [J]. EMBO JOURNAL, 1996, 15 (21) : 5849 - 5865
  • [56] THE SRF ACCESSORY PROTEIN ELK-1 CONTAINS A GROWTH FACTOR-REGULATED TRANSCRIPTIONAL ACTIVATION DOMAIN
    MARAIS, R
    WYNNE, J
    TREISMAN, R
    [J]. CELL, 1993, 73 (02) : 381 - 393
  • [57] Proteins of the ETS family with transcriptional repressor activity
    Mavrothalassitis, G
    Ghysdael, J
    [J]. ONCOGENE, 2000, 19 (55) : 6524 - 6532
  • [58] Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1
    McCarthy, SA
    Chen, D
    Yang, BS
    Ramirez, JJG
    Cherwinski, H
    Chen, XR
    Klagsbrun, M
    Hauser, CA
    Ostrowski, MC
    McMahon, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (05) : 2401 - 2412
  • [59] Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    McKercher, SR
    Torbett, BE
    Anderson, KL
    Henkel, GW
    Vestal, DJ
    Baribault, H
    Klemsz, M
    Feeney, AJ
    Wu, GE
    Paige, CJ
    Maki, RA
    [J]. EMBO JOURNAL, 1996, 15 (20) : 5647 - 5658
  • [60] Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: Insights into DNA sequence discrimination by ETS proteins
    Mo, Y
    Vaessen, B
    Johnston, K
    Marmorstein, R
    [J]. MOLECULAR CELL, 1998, 2 (02) : 201 - 212
12345678910