Less is more? STI in acute and chronic HIV-1 infection

被引:40
作者
Altfeld, M [1 ]
Walker, BD
机构
[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1038/90901
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Emerging data has indicated that supervised treatment interruption (STI) of highly active antiretroviral therapy might significantly augment immune responses in HIV-1-infected patients and slow disease progression. Here the authors discuss the rationale behind STI and future directions for study.
引用
收藏
页码:881 / 884
页数:4
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共 54 条
  • [31] Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men
    Lyles, RH
    Muñoz, A
    Yamashita, TE
    Bazmi, H
    Detels, R
    Rinaldo, CR
    Margolick, JB
    Phair, JP
    Mellors, JW
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (03) : 872 - 880
  • [32] Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection
    Malhotra, U
    Berrey, MM
    Huang, YJ
    Markee, J
    Brown, DJ
    Ap, S
    Musey, L
    Schacker, T
    Corey, L
    McElrath, MJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (01) : 121 - 131
  • [33] MARKOWITZ M, 2001, 8 C RETR OPP INF CHI
  • [34] Cellular immune responses to HIV
    McMichael, AJ
    Rowland-Jones, SL
    [J]. NATURE, 2001, 410 (6831) : 980 - 987
  • [35] HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors
    Migueles, SA
    Sabbaghian, MS
    Shupert, WL
    Bettinotti, MP
    Marincola, FM
    Martino, L
    Hallahan, CW
    Selig, SM
    Schwartz, D
    Sullivan, J
    Connors, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) : 2709 - 2714
  • [36] Structured treatment interruptions in antiretroviral management of HIV-1
    Miller, V
    [J]. CURRENT OPINION IN INFECTIOUS DISEASES, 2001, 14 (01) : 29 - 37
  • [37] Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure
    Miller, V
    Sabin, C
    Hertogs, K
    Bloor, S
    Martinez-Picado, J
    D'Aquila, R
    Larder, B
    Lutz, T
    Gute, P
    Weidmann, E
    Rabenau, H
    Phillips, A
    Staszewski, S
    [J]. AIDS, 2000, 14 (18) : 2857 - 2867
  • [38] Structured treatment interruptions to control HIV-1 and limit drug exposure
    Montaner, LJ
    [J]. TRENDS IN IMMUNOLOGY, 2001, 22 (02) : 92 - 96
  • [39] HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment
    Neumann, AU
    Tubiana, R
    Calvez, V
    Robert, C
    Li, TS
    Agut, H
    Autran, B
    Katlama, C
    [J]. AIDS, 1999, 13 (06) : 677 - 683
  • [40] Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
    Ogg, GS
    Jin, X
    Bonhoeffer, S
    Dunbar, PR
    Nowak, MA
    Monard, S
    Segal, JP
    Cao, YZ
    Rowland-Jones, SL
    Cerundolo, V
    Hurley, A
    Markowitz, M
    Ho, DD
    Nixon, DF
    McMichael, AJ
    [J]. SCIENCE, 1998, 279 (5359) : 2103 - 2106