Viral apoptotic mimicry

被引：241

作者：

Amara, Ali ^{[1
,2
]}

Mercer, Jason ^{[3
]}

机构：

[1] Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis, Inst Natl Sante & Rech Med U944, F-75010 Paris, France

[2] Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis,Inst Univ Hematol, Lab Pathol & Virol Mol,CNRS UMR 7212, F-75010 Paris, France

[3] UCL, Mol Cell Biol Lab, MRC, London WC1E 6BT, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 08期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MONKEY KIDNEY-CELLS; PHOSPHATIDYLSERINE RECEPTORS; CYTOKINE PRODUCTION; ALPHA-DYSTROGLYCAN; CELLULAR RECEPTOR; LIPID RAFTS; KINASE AXL; IDENTIFICATION; ENTRY;

D O I：

10.1038/nrmicro3469

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine - a marker for apoptosis - on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. Focusing on the four best described examples (vaccinia virus, dengue virus, Ebola virus and pseudotyped lentivirus), we summarize our current understanding of apoptotic mimicry as a mechanism for virus entry, binding and immune evasion. We also describe recent examples of non-enveloped viruses that use this mimicry strategy, and discuss future directions and how viral apoptotic mimicry could be targeted therapeutically.

引用

页码：461 / 469

页数：9

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