Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies

被引:310
作者
Bos, Peter A. [1 ]
Panksepp, Jaak [2 ]
Bluthe, Rose-Marie [3 ]
van Honk, Jack [1 ,4 ]
机构
[1] Univ Utrecht, Dept Expt Psychol, NL-3584 CS Utrecht, Netherlands
[2] Washington State Univ, Coll Vet Med, Dept VCAPP, Pullman, WA 99164 USA
[3] Univ Bordeaux 2, Unite Mixte Rech 1286, INRA, PsyNuGen, F-33076 Bordeaux, France
[4] Univ Cape Town, Dept Psychiat & Mental Hlth, J Block Groote Schuur Hosp Observ, ZA-7925 Cape Town, South Africa
关键词
Social behavior; Testosterone; Estradiol; Vasopressin; Oxytocin; Hormone administration; Humans; SUPERIOR TEMPORAL SULCUS; RODENT ANIMAL-MODELS; AGGRESSIVE-BEHAVIOR; INTRANASAL OXYTOCIN; EXOGENOUS TESTOSTERONE; ARGININE-VASOPRESSIN; NEURAL CIRCUITRY; SEX-DIFFERENCES; ANGRY FACES; BED NUCLEUS;
D O I
10.1016/j.yfrne.2011.01.002
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Steroids and peptides mediate a diverse array of animal social behaviors. Human research is restricted by technical-ethical limitations, and models of the neuroendocrine regulation of social-emotional behavior are therefore mainly limited to non-human species, often under the assumption that human social-emotional behavior is emancipated from hormonal control. Development of acute hormone administration procedures ill human research, together with the advent of novel non-invasive neuroimaging techniques, have opened up opportunities to systematically study the neuroendocrinology of human social-emotional behavior. Here, we review all placebo-controlled single hormone administration studies addressing human social-emotional behavior, involving the steroids testosterone and estradiol, and the peptides oxytocin and vasopressin. These studies demonstrate substantial hormonal control over human social-emotional behavior and give insights into the underlying neural mechanisms. Finally, we propose a theoretical model that synthesizes detailed knowledge of the neuroendocrinology of social-emotional behavior in animals with the recently gained data from humans described in our review. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:17 / 35
页数:19
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