Kruppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression

被引：27

作者：

Beak, Ju Youn ^{[1
]}

Kang, Hong Soon ^{[1
]}

Kim, Yong-Sik ^{[1
]}

Jetten, Anton M. ^{[1
]}

机构：

[1] NIEHS, LRB, Div Intramural Res,Cell Biol Sect, NIH, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

gli-similar; 3; mesenchymal stem cell; osteoblast; differentiation; BMP2; fibroblast growth factor 18; adipocyte;

D O I：

10.1359/JBMR.070503

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The zinc finger protein Glis3 is highly expressed in human osteoblasts and acts synergistically with BMP2 and Shh in enhancing osteoblast differentiation in multipotent C3H10T1/2 cells. This induction of osteoblast differentiation is at least in part caused by the induction of FGF18 expression. This study supports a regulatory role for Glis3 in osteoblast differentiation.

引用

页码：1234 / 1244

页数：11

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