Molecular dissection of neuromuscular junction formation

被引：13

作者：

Hoch, W ^{[1
]}

机构：

[1] Univ Houston, Houston, TX 77204 USA

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 07期

关键词：

D O I：

10.1016/S0166-2236(03)00131-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The muscle-specific kinase (MuSK) is the key component that mediates the synapse-inducing role of motoneuron-derived agrin at the neuromuscular junction. Recent reverse-genetics approaches have shed new light on the events triggered inside myotubes by activation of this kinase. Mice in which most of the intracellular domain of MuSK is replaced by a related kinase are viable. Analysis of the imperfect postsynaptic specializations of these mice has provided new insights into the complex postsynaptic differentiation process.

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页码：335 / 337

页数：3

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