FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders

被引：103

作者：

Hayette, S

Gadoux, M

Martel, S

Bertrand, S

Tigaud, I

Magaud, JP

Rimokh, R ^{[1
]}

机构：

[1] Ctr Leon Berard, INSERM, U453, F-69373 Lyon 08, France

[2] Hop Edouard Herriot, Lab Cytogenet Mol, F-69437 Lyon, France

来源：

ONCOGENE | 1998年 / 16卷 / 22期

关键词：

FLRG; follistatin; chromosomal translocation; carcinogenesis;

D O I：

10.1038/sj.onc.1201807

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here the molecular study of t(11;19)(q13;p13) translocation observed in a case of B-cell chronic lymphocytic leukemia. This translocation leads to the juxtaposition of the CCND1 gene on chromosome 11 to a new transcriptionnal unit on chromosome 19. The cDNA of this new evolutionarily conserved gene (named FLRG for Follistatin-Related Gene) codes for a secreted glycoprotein of the follistatin-module-protein family. FLRG is expressed in a wide range of human and murine adult tissues and its expression seems to be tightly regulated during murine embryogenesis. Its transcripts could not be detected in hematopoietic cells from all lineages and in particular in cells from lymphoid B and T lineage except in the t(11;19)-carrying leukemia described here. A great variability of expression is observed among the other tumoral cell lines analysed. Besides the t(11;19)-carrying leukemia described in this work, structural rearrangements of the FLRG locus have been found in a non-Hodgkin lymphoma, suggesting that it may play a role in leukemogenesis.

引用

页码：2949 / 2954

页数：6

共 23 条

[21] NONRANDOM CHROMOSOMAL REARRANGEMENTS OF 14Q32.3 AND 19P13.3 AND PREFERENTIAL DELETION OF 1P IN 21 PATIENTS WITH MULTIPLE-MYELOMA AND PLASMA-CELL LEUKEMIA [J].