Apoptosis-inducing activity of high molecular weight fractions of tea extracts

被引：49

作者：

Hayakawa, S

Kimura, T

Saeki, K

Koyama, Y

Aoyagi, Y

Noro, T

Nakamura, Y

Isemura, M ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Yada, Shizuoka 4228526, Japan

[2] Niigata Univ, Sch Med, Div Internal Med 3, Niigata 9518122, Japan

[3] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Yada, Shizuoka 4228526, Japan

[4] Univ Shizuoka, Sch Pharmaceut Sci, Yada, Shizuoka 4228526, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 02期

关键词：

epigallocatechin gallate; stomach cancer; tea; chemoprevention;

D O I：

10.1271/bbb.65.459

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High molecular weight fractions of green tea, black tea, oolong tea, and pu-erh tea were found to induce apoptosis in human monoblastic leukemia U937 cells by examination of their ability to inhibit cell proliferation and to induce apoptotic body formation and DNA ladder formation. These tea fractions were also shown to induce apoptosis in stomach cancer MKN-45 cells. In addition to known antitumor-promoting activity of tea high molecular weight fractions, their apoptosis-inducing activity may contribute to canter chemopreventive effects of tea.

引用

页码：459 / 462

页数：4

共 16 条

[1]

Ahmad N, 1999, NUTR REV, V57, P78, DOI 10.1111/j.1753-4887.1999.tb06927.x

[2] Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts [J].