Serum lipoprotein (a) concentrations among Arab children: a hospital-based study in Kuwait

被引：6

作者：

Alsaeid, M ^{[1
]}

Alsaeid, K ^{[1
]}

Fatania, HR ^{[1
]}

Sharma, PN ^{[1
]}

Abd-Elsalam, R ^{[1
]}

机构：

[1] Kuwait Univ, Fac Med, Dept Pediat, Safat 13110, Kuwait

来源：

ANNALS OF TROPICAL PAEDIATRICS | 1998年 / 18卷 / 03期

关键词：

D O I：

10.1080/02724936.1998.11747954

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Elevated lipoprotein (a) [Lp(a)] is an independent risk factor for premature atherosclerosis and coronary heart disease, both of which are prevalent among Kuwaitis. Our objective was to measure serum lipids, including Lp(a), in Arab children and compare them with values reported for other ethnic groups. To that end, serum concentrations of Lp(a), total cholesterol [T-CHOL], high density lipoprotein [HDL], low density lipoprotein [LDL], and triglyceride [TG] were assessed in 103 Arab children. The mean and median Lp(a) were 140.4 mg/l and 95 mg/l, respectively. The Lp(a) frequency distribution was skewed to the right with the highest frequencies appearing at low levels. Serum Lp(a) correlated positively with T-CHOL and LDL but did not correlate with age, HDL and TG. Only nine children (8.7%) had serum Lp(a) levels associated with increased cardiovascular risk, namely greater than or equal to 300 mg/l.

引用

页码：243 / 248

页数：6

共 24 条

[11] Growth hormone increases and insulin-like growth factor-I decreases circulating lipoprotein(a) [J].

Laron, Z ;

Wang, XL ;

Klinger, B ;

Silbergeld, A ;

Wilcken, DEL .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1997, 136 (04) :377-381

[12]

LAUER RM, 1992, PEDIATRICS, V89, P495

[13] LIPOPROTEIN(A), FIBRIN BINDING, AND PLASMINOGEN ACTIVATION [J].

LOSCALZO, J ;

WEINFELD, M ;

FLESS, GM ;

SCANU, AM .

ARTERIOSCLEROSIS, 1990, 10 (02) :240-245

[14] LIPOPROTEIN(A) - STRUCTURE, PROPERTIES AND POSSIBLE INVOLVEMENT IN THROMBOGENESIS AND ATHEROGENESIS [J].

MBEWU, AD ;

DURRINGTON, PN .

ATHEROSCLEROSIS, 1990, 85 (01) :1-14

[15]

*MIN HLTH KUW, NAT HLTH STAT 1994

[16] LP(A) LIPOPROTEIN AS A RISK FACTOR FOR CORONARY HEART-DISEASE AND CEREBRAL INFARCTION [J].

MURAI, A ;

MIYAHARA, T ;

FUJIMOTO, N ;

MATSUDA, M ;

KAMEYAMA, M .

ATHEROSCLEROSIS, 1986, 59 (02) :199-204

[17]

Ohji Taro, 1993, Acta Paediatrica Japonica, V35, P302

[18] DISTRIBUTION OF SERUM-LIPOPROTEIN (A) CONCENTRATIONS IN A HEALTHY TURKISH POPULATION [J].

OREM, A ;

DEGER, O ;

ONDER, E ;

KARAHAN, SC ;

EFE, H ;

UZUNOSMANOGLU, D .

ANNALS OF CLINICAL BIOCHEMISTRY, 1994, 31 :343-346

[19]

SANDHOLZER C, 1991, HUM GENET, V86, P607

[20] LIPOPROTEIN(A) - A GENETIC RISK FACTOR FOR PREMATURE CORONARY HEART-DISEASE [J].

SCANU, AM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (24) :3326-3329

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