Precise hit: Adeno-associated virus in gene targeting

被引：86

作者：

Vasileva, A

Jessberger, R ^{[1
]}

机构：

[1] Univ Technol Dresden, Inst Psyshiol Chem, Dresden, Germany

[2] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 11期

关键词：

D O I：

10.1038/nrmicro1266

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vectors based on the adeno-associated virus (AAV) have attracted much attention as potent gene-delivery vehicles, mainly because of the persistence of this non-pathogenic virus in the host cell and its sustainable therapeutic gene expression. However, virus infection can be accompanied by potentially mutagenic random vector integration into the genome. A novel approach to AAV-mediated gene therapy based on gene targeting through homologous recombination allows efficient, high-fidelity, non-mutagenic gene repair in a host cell.

引用

收藏

页码：837 / 847

页数：11

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